Chief Investigator: Rafał Dziadziuszko, MD, PhD
CLOVIS
Alicja Maciejewska-Izdebska MSc, CEEOG
A prospective study to evaluate the concordance of tumor-associated mutations detected in matched tumor and blood samples in patients with NSCLC with known epidermal growth factor receptor mutational status
01 December 2011
Closed
Study is designed to prospectively collect matched blood and tumor tissue from NSCLC patients with known EGFR mutation status. Eligible patients will undergo clinically indicated biopsy procedures. Specimen will be sent to central laboratory where DNA extracted from FFPE tumor tissue will be analyzed for all major EGFR mutations and compared to DNA isolated from matched blood samples (plasma and serum) to determine accordance. Limited clinical information on enrolled patients will be collected where available and will enclude demographics, data of initial diagnosis, date/type/duration of treatment administered, best overall response to each therapy, date if initial and subsequent biopsy and methodology/results of molecular characterization of tumor.
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Medical University of Gdańsk Department of Oncology and Radiotherapy 7 Dębinki Street, 80-211 Gdańsk, Poland |
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phone: +48 58 584 4560 e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. |