Central and East European Oncology Group

CLOVIS CO-1686-006 - A prospective study to evaluate the concordance of tumor-associated mutations detected in matched tumor and blood samples in patients with NSCLC with known epidermal growth factor receptor mutational status

Study team:

Chief Investigator: Rafał Dziadziuszko, MD, PhD

Sponsor:

CLOVIS

Study Coordinator:

Alicja Maciejewska-Izdebska MSc, CEEOG

Study title:

A prospective study to evaluate the concordance of tumor-associated mutations detected in matched tumor and blood samples in patients with NSCLC with known epidermal growth factor receptor mutational status

Start date:

01 December 2011

Study status:

Closed

Background:

Study is designed to prospectively collect matched blood and tumor tissue from NSCLC patients with known EGFR mutation status. Eligible patients will undergo clinically indicated biopsy procedures. Specimen will be sent to central laboratory where DNA extracted from FFPE tumor tissue will be analyzed for all major EGFR mutations and compared to DNA isolated from matched blood samples (plasma and serum) to determine accordance. Limited clinical information on enrolled patients will be collected where available and will enclude demographics, data of initial diagnosis, date/type/duration of treatment administered, best overall response to each therapy, date if initial and subsequent biopsy and methodology/results of molecular characterization of tumor.

 

CONTACT

home   
Medical University of Gdańsk
Department of Oncology and Radiotherapy
7 Dębinki Street, 80-211 Gdańsk, Poland
   
email   
phone: +48 58 349 22 54
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.